Monday, March 26, 2007

Losing weight without wheat

Trying the wheat free life

You can buy Pollenta - which is Maize flour -the coarse one is just great in most Asian shops. Look for large packets of Ginger powder and Cinnamon Powder – Cinnamon and ginger both have natural antibiotic properties, as do -by the way – apples. They are also GREAT digestion aids and anti flatulents and relieve nausea. Cinnamon is also and calming and also said to relieve menstrual cramps, and personally I find Ginger to be very cheering. AND best of all they hide the taste of bicarbonate of soda and cream of tartar, which are necessary as raising agents

Of course you can also use lemon juice to make a delicious lemon cake - coriander powder has a lovely lemony taste and is also a great digestive and apparently great for arthritis and rheumatism!!

You could probably make herb and cheese savoury versions, I certainly used to make a savoury oatmeal version for tea using baby nettles and other veg - great just don’t tell the kids what they are eating!!!

Be careful not to use red cheeses, which have harmful colorants. Cheshire and Wensleydale are clean and crumbly and free from additives. I used to make a kind of pancake using oatmeal instead of wheat for a pizza base

Also look for large bags of Jeera (cumin seed) and Fennel seed, both of which I use in my salads and are apparently great digestives, and Fennel Seed is said to help suppress the appetite – I suppose it satisfies some special body needs!!

Other ideas are baked potatoes – preferably organic because then you can eat the skins without too much damage to your innards! At present the only place I can buy organic potatoes is Royston Tesco

Cut several times into the potatoes and place in microwave hot setting max for around 6 mins

Take out and place in breakfast bowl. Open potatoes and drizzle in some oil (olive or Grapeseed) sprinkle lots of different herbs, mixed herbs, oregano and parsley are great, coriander too

Sprinkle on some sea salt

Back into microwave for 2 mins or just enough time for cheese to melt

Salads

Meanwhile tear up various lettuce add lots of herbs as above and some chopped white cheese ( Cheshire or Wensleydale is clean full of nutrients and delicious – you can get 3 packs for £3 both at Asda and Tesco Royston

Sprinkle in any seeds you fancy including jeera, fennel, and sunflower, sesame and pumpkin are nice

By the way sunflower and sesame go well in cake too!!

Chop in a banana, or tomatoes, or an avocado

Drizzle in a splash of olive oil, a splash of walnut oil, a splash of grape seed oil, a splash of pumpkin seed oil or avocado – mix them up look for others be adventurous – they all have wonderful properties – forget the cheap vegetable oils and add a splash of orange juice and or apple juice

I also use a splash of ginger cordial or elderflower cordial because I like sweet, especially if I add a splash of cider vinegar and / or curry powder – be adventurous

Stir it all up and bung it in a bowl with the baked potato

Also nice in the microwave is sliced mushroom laid on top of brown rivita and sliced white cheese on top with herbs and sea salt and several pieces cooked in microwave for around +/- 2 mins – as you like

instead of mushroom try tomatoe or sliced apples

You can also try – it’s a bit odd –eggy rivita – soak brown wheat free rivita in egg, milk, herb & sea salt mix and fry in olive oil

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Tuesday, March 13, 2007

Spiinal problems

a friend of mine suffered damage to vertebrae and spinal nerves from an accident at work

a year later she is happy to report huge improvement far beyond the original diagnosis thanks she says hugely to glucosamin - not something you can get proscribed on the NHS but the doctor told her it existed and to give it a go

she found it quite expensive - taking around 3 tablets a day but eventually found sources with sales and bulk purchase and she says definitely didn't feel a waste of her money although pretty cynical when she first started out

Glucosamin added to Chondroitin - seems to work better for cartilege repair
According to V R Pipitone (1991) - Chondroprotection with chondroitin sulphate. Drugs Experimental and Clinical Research 17:3 , chondroitin is :

  • '
  • reported to maintain viscosity in joints, stimulate cartilage repair mechanisms and inhibit enzymes that break down cartilage'

i have been looking at some sites and it seems that the liquid form is best

here is a site for bargain buys?

She also suggested a Tens machine but again have looked at sites and it seems that the Canadians may favour Ultrasound therapy to Tens repression :

also :

Barnett S C, Riddell J University of Glasgow, UK – 2005-2009 Promoting long-distance axonal regeneration and functional reconnection using combined treatments for spinal cord injury

'Several potential therapies have been developed to reverse the devastating consequences of spinal cord injury. At present, each therapy alone provides relatively modest improvements in injury models. Simultaneous treatment with different therapies is likely to improve the outcome, but it is essential that we establish which therapies to combine to achieve the maximum benefit and limit potential harmful effects.

'Earlier studies by Drs Riddell and Barnet have demonstrated that transplanting olfactory ensheathing glia (OEGs) into the injury site stimulates damaged nerve fibres to grow into and across the transplanted cells, but few of the newly grown fibres cross back into the undamaged spinal cord to establish functional connections with undamaged nerve fibres beyond the injury site. It is likely that scar tissue, which is particularly dense at the junction between the injury and undamaged spinal cord, blocks growth. Combining transplants of OEGs with additional treatments to boost the growth potential of nerve fibres and minimise growth inhibition might overcome the inhibitory effects of this scar tissue. In this project, researchers will combine transplants of OEGs with:

  • Chondroitinase, an enzyme that digest the inhibitory components in scar tissue, rendering it inactive
  • Growth factors, which boost the intrinsic growth potential of growing nerve fibres
  • LI> cAMP, which acts inside growing nerve fibres, making them more sensitive to growth factors and less sensitive to inhibitory molecules in the spinal cord.

'Combining the most promising treatments should maximise the regeneration potential of the spinal cord.'

but this research seems to be suggesting that Chondroitin is part of the problem :

Verhaagen J. Niclou S 2005 – 2008 Promoting axon regeneration in the injured spinal cord by RNAi-mediated knockdown of receptors for neurite growth inhibitors

'This project aims to stimulate the regeneration of nerve fibres in the injured spinal cord by using a powerful new technique called RNA interference to reduce the amount of inhibitory factors that are present at the injury site.

'In particular it will determine the contribution made by different types of inhibitory molecules to regeneration failure and proposes a combinatorial approach that blocks inhibitory influences at the injury site while, at the same time, stimulates the growth of injured nerve fibres with nerve growth factors.

'In the past 10 years, several inhibitors that block spinal cord regeneration after injury have been identified. The first two groups of inhibitors to be identified include myelin-based inhibitors (which include Nogo) and inhibitors in scar tissue, such as chondroitin sulphate proteoglycans (CSPGs for short). Another group of inhibitors associated with scar tissue, called semaphorins, has been identified more recently.

'We know that removing CSPGs from the lesion site promotes regeneration and functional recovery in rats with spinal cord injuries. In addition, blocking the effects of semaphorins increases the growth of nerve fibres in culture dishes, but the effect of preventing semaphoring activity in whole spinal cords has not been determined.

''Here, the objective is to promote the regeneration of nerve fibres in the injured spinal cord by blocking the effects of semaphorins as well as other types of inhibitory molecules that are associated with CNS myelin and scar tissue. Initially, this will involve a gene-therapy technique that will prevent cells in the spinal cord making the proteins that are involved with inhibitory effects. In a second stage, the group will combine this with growth factors to stimulate nerve growth.

Combining these two approaches should maximize regeneration following injury.'

Hmm

meanwhile Dr Zheng seeks to contribute more on the subject of somaphorins - how do they work

Zheng 2005 – 2008 The role of chemorepulsive axon guidance molecules, the semaphorins, in adult CNS axon regeneration failure

'There are many reasons why nerve fibres in the brain and spinal cord of adult mammals do not regenerate following injury. One reason is that these tissues contain many inhibitory factors. Some of these, such as Nogo, form part of the protective myelin coating that surrounds nerve fibres, whereas others, including CSPGs, are present in the scar tissue that forms at the injury site.

'Recently, it has been shown that another group of inhibitory factors, called semaphorins, are also present in scar tissue in the spinal cord.

'The inhibitory effects of semaphorins on the growth of nerve fibres when the nervous system develops have been studied extensively. These studies show that semaphorins both stop and ‘repulse’ the growth of nerve fibres in the developing foetus. Thus, during development, inhibition by semaphorins has a role in preventing the nerve fibres growing into inappropriate positions and ensuring they grow to their correct destinations.

'In adults, it is possible that these same molecules contribute to the regeneration failure following spinal cord injury. However, this has not been tested directly.

'Dr Zheng plans to assess the contribution of semaphorins in regeneration failure by identifying the location and concentration of semaphorins after spinal cord injuries in different species. If the pattern of changes is similar in different species, the role of these molecules after spinal cord injury might also be similar. However, if the pattern of changes differs significantly between species, the role of these molecules might also differ, which is important when we consider spinal cord injuries in humans.

'This work will establish whether semaphorins restrict spinal cord regeneration in adult mammals and could identify another inhibitory factor to be targeted to achieve spinal cord regeneration in humans.'

and Pokrupa et all develop their methods to use fMRI (functional Magnetic Resonance Imaging to actually trace and measure nerve activity in the spinal cord which might be useful in assessing further treatments

Pokrupa R. Smith R. Smith K, Stroman P. 2005 – 2008 Development of functional magnetic resonance imaging for assessing human spinal cord injuries

'Nerve activity in the brain can be measured accurately using a non-invasive technique called functional magnetic resonance imaging (fMRI). In this project scientists are developing fMRI further, to provide a sensitive way to measure nerve activity in the spinal cords of injured patients.

'In the early 1990s it was proposed that fMRI might be used to measure nerve activity in the brain. Since then, the technique has developed rapidly and it is now a proven method for mapping the small changes in brain activity that are associated with various physical and mental stimuli. More recently, it was proposed that fMRI might accurately measure nerve activity in various areas of the spinal cord.

'At present, the extent of damage to the spinal cord is assessed mainly by the extent of paralysis and whether a patient can feel sensation at various points on the body. Although useful clinically, these techniques provide relatively gross indications of the exact damage within the spinal cord. Using fMRI it should be possible to map exact changes anywhere in the spinal cord, including above, below and at the injury site. As a result, small changes in nerve activity in the spinal cord that occur as a result of treatment might be detected, even though the patient’s sensory or motor abilities might not change. This information could be used to assess the effectiveness of a treatment, and to alter the treatment strategy if necessary to achieve the best possible outcome.

'Although based on the methods developed for the brain, fMRI of the spinal cord requires special modifications, and Dr Stroman is the leading expert on the use of fMRI in the spinal cord. In normal individuals, he has developed spinal fMRI to detect changes in the spinal cord evoked by changes in temperature and, in patients with complete spinal cord injuries he can measure nerve activity in the spinal cord above the injury site. Recent data images up to 12 cm of the cord in three dimensions.

'However, the results vary, even in repeated experiments in the same subject, so the existing method is not yet adequate for clinical assessment. In order to achieve this, the group intend to determine the sources of error, which will be used to further develop data acquisition and analysis methods to increase the accuracy and reproducibility of the technique.'


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Friday, March 09, 2007

it's only natural

Would it be fair to say that team efficiency depends on the positive effect of strong individual/s within the team, but lack of self confidence can result in team members being manipulated and therefore causing a negative effect on team performance.

What is the cost to the community when efforts of good workers are eroded by negative controls on team efficiency?

When the success of the task or chance of task being performed to maximum result depends on the strength of belief in efficacy of task held by these same strong individuals, teams slack or work, take shortcuts or use initiative, experience and knowledge to perform the task to their utmost ability

When teams tick by on minimal result, minimal effort, cultures of reporting innocuous behaviours can allow manipulative individuals thriving within the group to effectively eradicate any challenge, dream up complications and camouflage negative effects until it is too late

So when workers are not allowed to perform to their best ability is it not unreasonable to assume that resulting discontent and shame are manifest in escapist activities, ie alcohol and drugs, legal or proscribed